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Abstract
Cladosporine A (1), a new indole diterpenoid alkaloid, was isolated from the extract of a fungal strain Cladosporium sp. JNU17DTH12-9-01. Its structure was elucidated by extensive spectroscopic analysis, and the absolute configurations were determined by electronic circular dichroism (ECD) experiments. This is the first report of the presence of indole diterpenoid alkaloid in the genus Cladosporium. The antimicrobial activities against Staphylococcus aureus 209P, Escherichia coli ATCC0111, Aspergillus niger R330, and Candida albicans FIM709 were evaluated. Compound 1 showed MICs of 4 μg/mL and 16 μg/mL against S. aureus 209P and C. albicans FIM709, respectively.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by grants from the National Natural Science Foundation of China [No. 3171101305], Chang Jiang Scholars Program [No. Hao Gao, 2017] from the Ministry of Education of China, Guangdong Special Support Program [No. 2016TX03R280], Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine [No. QNRC2-B06], Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme [No. Hao Gao, 2014], Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [No. 2017BT01Y036], and K. C. Wong Education Foundation [No. Hao Gao, 2016]. We are thanks to the high-performance computing platform of Jinan University.