Two new steroids with NO inhibitory effects from lansium domesticum

Abstract

Chemical investigation of Lansium domesticum has led to the isolation of two undescribed compounds, namely 17(20)E-dyscusin B (1) and 17(20)Z-dyscusin B (2), as well as three known ones (3 – 5). Structural elucidation was accomplished by the analysis of NMR, MS and IR data. Compounds 1 and 2 were a pair of Δ¹⁷⁽²⁰⁾ geometric isomers of pregnane steroids and showed the significant nitric oxide (NO) inhibitory activities.

GRAPHICAL ABSTRACT

Keywords:

• Lansium domesticum
• steroids
• NO inhibition
• Meliaceae

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the 135 Programs of Xishuangbanna Tropical botanical Garden (XTBG), Chinese Academy of Sciences (CAS) under Grant XTBG-F02.