Abstract
The aerial portions of Cynara scolymus commonly have been eaten as vegetables or functional foods by the people lived in Mediterranean region. In preliminary antioxidant screening, the rhizome portions (CSR) of this species showed better potential than leaves ones. However, neither phytochemical nor pharmacology studies of CSR have been reported to date. The purpose of this research was to identify the active components from CSR through bioassay-guided fractionation. The antioxidant properties of secondary metabolites 1–9 were evaluated in this investigation. Compounds 4–6, 8, and 9 showed antioxidant activities based on DPPH free radical scavenging activity with IC50 values of 22.91–147.21 μM. Besides, compound 8 significantly and dose-dependently reduced H2O2-induced ROS levels in keratinocyte HaCaT cells without cytotoxicity toward HaCaT. Overall, our studies demonstrated the rhizome of C. scolymus could be used as a new natural antioxidant like the edible aerial portions and phenolic compounds are the active components.
Graphical Abstract
Acknowledgements
This work was financially supported by Ministry of Science and Technology (MOST 106-2622-B-037-003-CC2 and MOST 107-2622-B-037-001-CC2), Taiwan awarded to Y.C. Wu and China Medical University (CMU107-S-34) Taiwan awarded to C.L. Lee.
Disclosure statement
No potential conflict of interest was reported by the authors.