Abstract
A new dineolignan, crataeguslignan A (1), along with one known dineolignan (2) were isolated from the fruits of Crataegus pinnatifida Bge. Its chemical structure was identified by comprehensive spectroscopic analyses. All the isolated compounds were investigated with regard to their Aβ1–42 inhibition activity. Among them, 1 displayed the most potent Aβ1–42 inhibitory ability with the inhibition rate of 85.2% at the concentration of 20 μM.
Graphical Abstract
Acknowledgments
This work was supported by Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (ZQN2018006) and the Project of Innovation Team Foundation (LT2015027).