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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 13
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Research Articles

Pregnane glycosides from Gymnema inodorum and their α-glucosidase inhibitory activity

Do Thi Tranga Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Duong Thi Hai Yena Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Nguyen The Cuongb Institute of Ecology and Biological Resources, VAST, Hanoi, VietnamView further author information
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Luu The Anhc Central Institute for Natural Resources and Environmental Studies, Vietnam National National University, Hanoi, VietnamView further author information
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Nguyen Thi Hoaid Faculty of Pharmacy, Hue University of Pharmacy and Medicine, Hue, VietnamView further author information
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Bui Huu Taia Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;e Graduate University of Science and Technology, VAST, Hanoi, VietnamView further author information
,
Vu Van Doana Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
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Pham Hai Yena Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Tran Hong Quanga Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Nguyen Xuan Nhiema Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;e Graduate University of Science and Technology, VAST, Hanoi, VietnamView further author information
,
Chau Van Minha Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
&
Phan Van Kiema Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;e Graduate University of Science and Technology, VAST, Hanoi, VietnamCorrespondence[email protected] [email protected]
View further author information
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Pages 2157-2163 | Received 09 Jul 2019, Accepted 22 Aug 2019, Published online: 11 Sep 2019
 
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Abstract

Two new pregnane glycosides, gyminosides A and B (1 and 2) and three known, tinctoroside B (3), tinctoroside C (4), and gymnepregoside F (5) were isolated from the leaves of Gymnema inodorum (Lour.) Decne. Their structures were elucidated by physical and chemical methods and comparing with those reported in the literature. All these compounds were evaluated for α-glucosidase assay. Compound 5 exhibited the most anti α-glucosidase activity with inhibitory percentage of 63.7 ± 3.9% at the concentration of 200 μM. Compounds 1–4 showed moderate anti α-glucosidase activity with inhibitory percentage ranging from 40.0 to 52.1%.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2017.25.

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