Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis

Abstract

This research isolated two new oleanane-type triterpene glycosides, named mocochinosides A (1) and B (2), together with ten known compounds as chikusetsusaponin IVa ethyl ester (3), momordin Ib (4), momordin IIb (5), momordin II (6), calenduloside G (7), calenduloside H (8), elatoside A (9), elatoside C (10), calendulaglycoside C 6'-O-7-butyl ester (11), and hederagenin 3-O-β-D-glucuronopyranoside (12) and characterized them from the vines of Momordica cochinchinensis. The new structures of both glycosides 1-2 were elucidated by spectroscopic analysis including 2 D NMR and MS, followed by an analysis of their anti-inflammatory and cytotoxic activities. Compounds 1, 4, and 11 showed moderate inhibitions for NO production on RAW264.7 macrophages induced by LPS at IC₅₀ 5.41 ∼ 11.28 μM. Compounds 3, 4, and 7 (IC₅₀ 8.42 ∼ 19.74 μM) exhibited potential anti-proliferative activities against both of WiDr and MCF-7 human tumor cell lines.

GRAPHICAL ABSTRACT

Keywords:

• Momordica cochinchinensis
• oleanane-type triterpene glycoside
• mocochinoside
• anti-inflammatory
• anti-proliferation

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by grants from the Taiwan seed improvement and propagation station, National Science Council (NSC098-2811-B-077-002 and NSC98-2320-B-077-005-MY3) and Ministry of Science and Technology (MOST104-2320-B-077-006-MY3), as well as from the Ministry of Health and Welfare (MM10601-0160, MOHW107-NRICM-M-315-134001 and 108-NRICM-M-315-144001).