A new epimer of azaphilone derivative pinophilin B from the gorgonian-derived fungus Aspergillus fumigatus 14–27

Abstract

A new epimer of azaphilone derivative pinophilin B, epi-pinophilin B (1), and three known analogues (2–4) were obtained from the culture of the gorgonian-derived fungus Aspergillus fumigatus 14–27. The structures of 1–4, including their relative configurations were determined by extensive spectroscopic analysis and comparing with literature data. The absolute configuration of 1 was determined by electronic circular dichroism (ECD) and optical rotatory (OR) calculations methods. Compounds 1–4 were isolated from A. fumigatus for the first time. Their antibacterial and cytotoxic activities were also evaluated.

Graphical Abstract

Keywords:

• Aspergillus fumigatus
• azaphilone derivative
• absolute configuration

Acknowledgements

We thank all the authors who contributed to this paper.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (Nos. 41606174; 81673350; 41830535), the Fundamental Research Funds for the Central Universities of China (No. 201762017), the High-Performance Computer Center of Hebei University and the Taishan Scholars Program, China.