Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Aquilaria crassna Pierre ex Lecomte in Laos

Abstract

Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone were isolated from the agarwood of Aquilaria crassna Pierre ex Lecomte in Laos. The structures of the isolates were elucidated by spectroscopic methods, and their configurations were determined via ROESY correlations, ³ J _H-H coupling constants analyses, comparisons of chemical shifts and specific rotations with known compounds, and ECD calculation in the case of 1. Compounds 1–4 were evaluated for their cytotoxicity. Compounds 1 and 2 exhibited weak cytotoxicity toward HeLa cell line (IC₅₀: 49.8 ± 1.2 μM) and K562 cell line (IC₅₀: 42.66 ± 0.47 μM), respectively.

Graphical Abstract

KEYWORDS:

• Agarwood
• Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae)
• 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Innovative Research Team Grant of the Natural Science Foundation of Hainan Province (No.2017CXTD020), Central Public-interest Scientific Institution Basal Research Fund for Innovative Research Team Program of CATAS (17 CXTD-15), China Agriculture Research System (CARS-21), and Grant of Postdoctoral General Program of Hainan Province.