Five polyketides isolated from the marine-derived fungus Arthrinium Sp.

Abstract

Four new polyketides including two arthrinic acid derivatives (1–2), one phenolic derivative (3) and (S)-3-hydroxy-6-(2-hydroxypropyl)-5-methyl-2H-pyran-2-one (4) along with one methyl ester of arthrinic acid (5) were isolated from the culture broth of Arthrinium sp., which was an entophytic fungus of clam worm. Their structures were identified on the basis of HR-ESI-MS and NMR spectral analyses together with advanced Mosher's method. In the assay of inhibiting the prostate cancer PC3 cell line, none of the isolated compounds showed significant cytotoxicity.

Graphical Abstract

Keywords:

• Polyketide
• arthrinic acid
• Arthrinium sp.
• marine-derived fungus

Acknowledgements

We thank Ying Liu (Ocean College, Zhejiang University) for performing NMR spectroscopy.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Natural Science Foundation of China (NSFC No.41406141) and Natural Science Foundation of Zhejiang Province (LY18D060003).