A new antimicrobial indoloditerpene from a marine-sourced fungus aspergillus versicolor ZZ761

Abstract

A new indoloditerpene (1) and fifteen known compounds (2–16) were isolated from a marine-derived fungus Aspergillus versicolor ZZ761. Structure of the new compound was elucidated as (3 R,9S,12R,13S,17S,18S)-2-carbonyl-3-hydroxylemeniveol based on its HRESIMS data, NMR spectroscopic analyses, the Mosher′s method, and ECD calculation. This new indoloditerpene (1) showed antimicrobial activities with MIC values of 20.6 μM against Escherichia coli and 22.8 μM against Candida albicans. Diorcinol (2) and versicolorin B (6) had activities in inhibiting the proliferation of human glioma U87MG and U251 cells with IC₅₀ values of 4.4 and 6.2 μM and 11.3 and 30.5 μM, respectively.

Graphical Abstract

Keywords:

• Aspergillus versicolor ZZ761
• (3R,9S,12R,13S,17S,18S)-2-carbonyl-3-hydroxylemeniveol
• antimicrobial and antiproliferative activities

Supplementary material

The experimental section, HRESIMS, NMR, IR, and UV spectra of 1 as well as ¹³C and ¹H NMR data of compounds 1–16 are available in the Supplementary Material.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the National Key R&D Program of China (No. 2018YFC0311002) and the National Natural Science Foundation of China (No. 81773587).