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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 15
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Short Communications

Octyl substituted butenolides from marine-derived Streptomyces koyangensis

Hongbo Huanga CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China;b School of Oceanology, University of Chinese Academy of Sciences, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0002-5235-739XView further author information
ORCID Icon,
Yongxiang Songa CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China;b School of Oceanology, University of Chinese Academy of Sciences, Beijing, ChinaView further author information
,
Ruochen Zangc Innovative Marine Drug Screening and Evaluation Center, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaView further author information
,
Xin Wangc Innovative Marine Drug Screening and Evaluation Center, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaView further author information
&
Jianhua Jua CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China;b School of Oceanology, University of Chinese Academy of Sciences, Beijing, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7712-8027View further author information
ORCID Icon
Pages 2602-2607 | Received 10 Jun 2019, Accepted 25 Oct 2019, Published online: 06 Nov 2019
 
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Abstract

A new butenolide derivative (1) featuring octyl substitution at γ-position, together with four known analogues (2–5) were isolated from marine-derived Streptomyces koyangensis SCSIO 5802. The structure of 1 was elucidated by HR-MS and NMR spectroscopic data analyses. The absolute configuration of the stereo centre in lactone ring of 1 was determined by comparison of CD spectrum with those of known compounds. Compound 1 exhibited mild antiviral activity against herpes simplex virus with EC50 value of 25.4 µM.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported in part by the National Natural Science Foundation of China (41476133, 41676151, and 81425022). We thank Dr Xiao, Ms. Sun, Ms. Zhang and Ms. Ma in the analytical facility at SCSIO for recording MS and NMR spectroscopic data.

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