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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 19
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Short Communications

New dihydrobenzofuranoid from the marine-derived fungus Aspergillus ustus KMM 4664

Galina K. Oleinikovaa Laboratory of Chemistry of Microbial Metabolites, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russian Federation
,
Olesya I. Zhuravlevaa Laboratory of Chemistry of Microbial Metabolites, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russian Federation;b Far Eastern Federal University, Vladivostok, Russian FederationCorrespondence[email protected]
,
Dmitrii V. Berdysheva Laboratory of Chemistry of Microbial Metabolites, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russian Federation
,
Natalia I. Menzorovaa Laboratory of Chemistry of Microbial Metabolites, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russian Federation
,
Roman S. Popova Laboratory of Chemistry of Microbial Metabolites, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russian Federation
,
Vladimir A. Denisenkoa Laboratory of Chemistry of Microbial Metabolites, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russian Federation
,
Natalya N. Kirichuka Laboratory of Chemistry of Microbial Metabolites, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russian Federation
&
Shamil Sh. Afiyatullova Laboratory of Chemistry of Microbial Metabolites, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russian FederationCorrespondence[email protected]
 show all
Pages 3332-3335 | Received 05 Jul 2019, Accepted 29 Oct 2019, Published online: 15 Nov 2019
 
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Abstract

One new dihydrobenzofuran derivative (1), known depsipeptide emericellamide A (2), three known drimanes (3–5) and two artifact drimane derivatives (6, 7) were isolated from the marine-derived fungus Aspergillus ustus KMM 4664. Their structures were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configuration of 1 was determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 7 showed significant ability of the inhibition of spermatozoa to fertilize egg-cells of the sea urchin Strongylocentrotus intermedius with IC50 value 21 µM.

Acknowledgements

The study was carried out using the equipment and resources of the Collective Facilities Center ‘The Far Eastern Center for Structural Molecular Research (NMR/MS) PIBOC FEB RAS’ and the Collective Facilities Center ‘Collection of Marine Microorganisms PIBOC FEB RAS’.

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