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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 18
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Himatanthus bracteatus stem extracts present anti-flavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro

Marlene Lourenço da Silvaa Departamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilView further author information
,
João Renato Stehmannb Departamento de Botânica, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilView further author information
,
Mateus Sá Magalhães Serafimc Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilView further author information
,
Valdicley Vieira Valed Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, Belém, BrazilView further author information
,
Douglas Costa Gontijoa Departamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7759-9694View further author information
ORCID Icon,
Geraldo Célio Brandãoe Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, BrazilORCID Iconhttps://orcid.org/0000-0002-7330-051XView further author information
ORCID Icon,
Erna Geessien Kroonc Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilView further author information
&
Alaíde Braga de Oliveiraa Departamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0374-8909View further author information
ORCID Icon show all
Pages 3161-3165 | Received 23 Aug 2019, Accepted 03 Nov 2019, Published online: 20 Nov 2019
 
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Abstract

The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI) > 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97).

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Disclosure statement

The authors confirm that this article content has no conflict of interest.

Additional information

Funding

To FAPEMIG Process APQ-01410-14 for financial support to ABO. To CNPq Process 440911/2016, Capes Process 2058/2016 and DECIT/MS for financial support to EGK. To CNPq for scholarship to MLS and fellowship to ABO.

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