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Abstract
Two new mertoterpenoids, australins A (1) and B (2), and a new alkaloid, australine (4), together with five known compounds (3, 5–8) were isolated from the fruiting bodies of Ganoderma australe. Their structures including absolute configurations were assigned by using spectroscopic methods and electronic circular dichroism (ECD) calculations. Racemic australin A was further purified by chiral HPLC. Biological assessments reveal that compounds (+)-1 and 7 could significantly protect SH-SY5Y cells from glutamate-induced neural excitotoxicity.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by National Science Fund for NSFC-Joint Foundation of Yunnan Province (U1702287), Distinguished Young Scholars (81525026), National Natural Science Foundation of China (31700932), National Key Research and Development Program of China (2017YFA0503900), Shenzhen Science and Technology Innovation Committee for Basic Research (JCYJ20170307170742519).