Two new phenylpropanoids and a new dihydrostilbenoid from the flower buds of Magnolia biondii pamp and their acetylcholinesterase inhibitory activities

Abstract

Two new phenylpropanoids, named (2'R*,3'R*)-2',3'-dihydroxy-4'-methoxy-caffeoyl butyrate (1), 9-acetoxy syringin (2), and a new dihydrostilbene, named (8'R)-4',5-dihydroxy-4,8'-dimethoxy-2-hydroxyethyl diphenylethane (3), together with five analogues (4–8), were isolated from the flower buds of Magnolia biondii Pamp. Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. The absolute configurations were deduced by comparison of experimental and calculated gauge-independent atomic orbital (GIAO) 1 D NMR data. Moreover, the isolated compounds (1–8) were evaluated in vitro for their acetylcholinesterase (AChE) inhibitory activities.

Keywords:

• Magnolia biondii Pamp
• Magnoliaceae
• phenylpropanoids
• dihydrostilbenoids
• acetylcholinesterase inhibitory activity

Disclosure statement

The authors declare no conflicts of interest.

Additional information

Funding

This work was supported by the Central Leading Local Science and Technology Development Special Foundation ([2016]149) and Science and Technology Key Project of Henan Province (182102410080).