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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 22
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Short Communications

Towards a new application of amaranth seed oil as an agent against Candida albicans

Daniela De Vitaa Department of Environmental Biology, University of Rome “La Sapienza”, Rome, Italy
,
Antonella Messoreb “Istituto Pasteur-Fondazione Cenci Bolognetti”, Department of Chemistry and Technology of Drug, University of Rome “La Sapienza”, Rome, Italy
,
Chiara Tonioloa Department of Environmental Biology, University of Rome “La Sapienza”, Rome, Italy
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Claudio Frezzaa Department of Environmental Biology, University of Rome “La Sapienza”, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-2968-5264
ORCID Icon,
Luigi Scipioneb “Istituto Pasteur-Fondazione Cenci Bolognetti”, Department of Chemistry and Technology of Drug, University of Rome “La Sapienza”, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-2006-7005
ORCID Icon,
Cinzia Margherita Berteac Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy
,
Marco Micerac Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy;d Exenia Group S.R.L, Pinerolo, Torino, Italy
,
Veronica Di Sarnoe Department of Pharmacy, University of Salerno, Fisciano, Italy
,
Valentina Noemi Madiab “Istituto Pasteur-Fondazione Cenci Bolognetti”, Department of Chemistry and Technology of Drug, University of Rome “La Sapienza”, Rome, Italy
,
Ivano Pindinellob “Istituto Pasteur-Fondazione Cenci Bolognetti”, Department of Chemistry and Technology of Drug, University of Rome “La Sapienza”, Rome, Italy
,
Patrizia Roscillid Exenia Group S.R.L, Pinerolo, Torino, Italy
,
Alfonso Bottod Exenia Group S.R.L, Pinerolo, Torino, Italy
,
Giovanna Simonettia Department of Environmental Biology, University of Rome “La Sapienza”, Rome, ItalyCorrespondence[email protected] [email protected]
,
Anastasia Orekhovaf Department of “Sanità Pubblica e Malattie Infettive”, Sapienza University of Rome, Rome, Italy
,
Stefano Manfredinig Department of Life Science and Biotechnology, University of Ferrara, Ferrara, Italy
,
Roberta Costib “Istituto Pasteur-Fondazione Cenci Bolognetti”, Department of Chemistry and Technology of Drug, University of Rome “La Sapienza”, Rome, ItalyCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-1314-9029
ORCID Icon &
Roberto Di Santob “Istituto Pasteur-Fondazione Cenci Bolognetti”, Department of Chemistry and Technology of Drug, University of Rome “La Sapienza”, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-4279-7666
ORCID Icon show all
Pages 4621-4626 | Received 16 Oct 2019, Accepted 10 Nov 2019, Published online: 04 Dec 2019
 
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Abstract

Amaranthus spp. (Amaranthaceae family), known as amaranth, are plants native of Central America, today produced in many parts of the world. due to their popularity popular as a health food. Because of its composition, amaranth can be considered to be attractive not only as a food but also for pharmaceutical and cosmetics uses. To date, antifungal activity of amaranth extracts has not been totally investigated, therefore the scope of this study was to evaluate the antifungal effect of the apolar fraction from Amaranthus cruentus L. seeds extract, alone and in association with antifungal drugs terbinafine, a common antifungal agent, which itself has only fungistatic effect on Candida albicans strains without exerting fungicidal activity. Our results demonstrate that this amaranth oil in combination with terbinafine has synergic fungistatic and fungicidal activity, with FICI of 0.466 and 0.496, respectively. No fungistatic and fungicidal activity of terbinafine alone at concentrations up to 64 μg/mL and amaranth oil alone at concentrations up to 2000 μg/mL, against all tested C. albicans strains, were observed. does not show activity towards Candida albicans strains but it can effectively potentiate the antifungal activity of terbinafine, a common antifungal agent which itself This result suggests the possible application of amaranth oil in the preparation of formulations with terbinafine for topical use.

Graphical Abstract

Disclosure statement

The authors declare no conflict of interest.

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