Chemical constituents of Trillium tschonoskii Maxim.

Abstract

A new fatty acid-spirostan steroid glycoside ester, a new cholestane glycoside and a new stilbene trimer, along with three known steroidal saponins, were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium tschonoskii Maxim. The structure of isolated compounds was elucidated by spectroscopic analysis. Compound 1–6 were assessed for their cytotoxicity against cancer cell lines (MCF-7, HCT-116, DU-145, SGC-7901, MCF-7/ADR, K562/ADR), and the result showed that compound 4 was highly toxic to six human tumor cell lines.

Graphical Abstract

Keywords:

• Trillium tschonoskii Maxim.
• steroidal saponins
• antitumor activities

Acknowledgments

The work was supported by National Natural Science Foundation of China (NO. 81473423) and Liaoning Provincial Department of Education(2019LJC09).

Disclosure statement

The authors declare that there are no conflicting interest.