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Abstract
Two new lignans, noreucol A (1) and (+)-epicycloolivil (2), along with seven known compounds (3–9) were isolated from the aqueous extract of Eucommia ulmoides Oliver. Compound 1 was a new norlignan and 2 was an epimer at C-7 of (+)-cycloolivil (3). Their structures were elucidated by spectroscopic methods, and the absolute configurations of new compounds were determined by conformational analysis and DFT theoretic electronic circular dichroism spectra calculations. In addition, the neuroprotective activity of compounds 1–3 against glutamate-induced HT-22 cells injury were evaluated, and only compound 1 exhibited moderate effect at the concentrations ranging from 10 ∼ 50 μM.
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There is no potential conflict of interest for authors
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Funding
This work was financially supported by the National Development of Key Novel Drugs for Special Projects of China (2017ZX09304014), the Special Research for Traditional Chinese Medicine Industry (201507004-4-3), National Natural Science Foundation of China [grant number 31700303], Natural Science Foundation of Hunan Province [grant numbers 2018JJ3839 and 2019JJ50966]. This work was also supported by the Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples (2017TP1037).