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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 22
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Short Communications

Pro-apoptoticeffect of diterpenoids from Fokienia hodginsii on acute myeloid leukemia cells

Dang Viet Haua Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Nguyen Hoang Sab Department of Natural Products Research, Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;c Department of Science and Technology, Khanh Hoa University, Nha Trang, VietnamView further author information
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Nguyen Thanh Tama Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;b Department of Natural Products Research, Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Nguyen Thi Diepb Department of Natural Products Research, Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
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Nguyen Thi Hoang Anha Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;b Department of Natural Products Research, Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
,
Nguyen Thi Thuy Linha Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;b Department of Natural Products Research, Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamView further author information
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Huynh Thi Ngoc Nid Department of Chemistry, Phu Yen University, Phu Yen, VietnamView further author information
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Sabrina Adorisioe Foligno Nursing School, University of Perugia, Perugia, ItalyView further author information
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Domenico V. Delfinoe Foligno Nursing School, University of Perugia, Perugia, Italy;f Section of Pharmacology, Department of Medicine, University of Perugia, Perugia, ItalyCorrespondence[email protected]
View further author information
&
Trinh Thi Thuya Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;b Department of Natural Products Research, Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamCorrespondence[email protected]
View further author information
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Pages 4685-4689 | Received 06 Aug 2019, Accepted 02 Dec 2019, Published online: 24 Dec 2019
 
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Abstract

Previously, we isolated four known diterpenoids, trans-communic acid (1), 13-oxo-15,16-dinor-labda-8(17), 11E-diene-19-oic acid (2), 3β-hydroxytotarol (3), and totarolone (4) from Fokienia hodginsii leaves. Further study demonstrated the antiproliferative activity of all four compounds in acute myeloid leukemia (OCI-AML) cells due to impaired cell cycle progression. Interestingly, 3β-hydroxytotarol (3) had very powerful bioactivity at low concentrations (5 µg/mL).

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors thank the Vietnam Ministry of Science and Technology under project (grant number NDT.33.ITA/17) and Italian Ministero degli Esteri e della Cooperazione Internazionale (grant number MAECI) for financial support.

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