Anti-inflammatory activity of the epicuticular wax and its isolated compounds catechin and gallocatechin from Eugenia brasiliensis Lam. (Myrtaceae) leaves

Abstract

This study describes anti-inflamatory activity of epicuticular wax (ECW) extracted from leaves of Eugenia brasiliensis Lam., and its isolated compounds, catechin and gallocatechin in a pleurisy model in mice. The results for exudation and cell migration showed that the extract and isolated compounds from the plant were effective in inhibiting these inflammatory parameters. The ECW demonstrated a dose-dependent effect on the inhibition of cell migration. The results for NO_x levels reveals that the isolated compounds from Eugenia brasiliensis were effective in inhibiting the production of this inflammatory mediator, however, ECW were not able in inhibiting the production of NO in the pleural cavity, at the tested doses. The results here obtained, helps to reinforce the scientifically hypothesis that E. brasiliensis has an important anti-inflammatory activity, and that this effect may be, at least in part, by the presence of the compounds catechin and gallocatechin.

Graphical Abstract

KEYWORDS:

• E. brasiliensis
• epicuticular wax
• catechin
• gallocatechin
• anti-inflammatory

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors are grateful to CAPES, FURB and UFSC for the financial and technical support.