New compounds from the aerial parts of Justicia gendarussa Burm.f. and their antioxidant and anti-inflammatory activities

Abstract

Three new compounds (1–3), together with six known compounds (4–9), were isolated from the ethyl acetate fraction of ethanol extract of the aerial parts of Justicia gendarussa Burm.f. All of these known compounds were isolated from the plant for the first time. Their structures including absolute configurations were elucidated on the basis of HR-ESI-MS, NMR spectroscopic analyses, single crystal X-ray diffraction and comparison with the literatures. Compounds 1–9 were tested for their antioxidant and anti-inflammatory activities. Compounds 5 and 8 showed the antioxidant activities with IC₅₀ values of 28.61 ± 1.56 and 22.55 ± 1.38 μM, respectively. Compounds 2 and 3 showed anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC₅₀ values of 20.95 ± 1.11 and 16.50 ± 1.04 μM, respectively.

Graphical Abstract

Keywords:

• Justicia gendarussa Burm.f.
• X-ray diffraction
• antioxidant activity
• anti-inflammatory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the grant (2017-110108-83-03-001423) from State Bureau of Chinese Medicine, the National Natural Science Foundation of China (No. 81573578) and Guangzhou Project of Science and Technolegy (201704030120).