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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 20
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Research Articles

A new alkynol compound from Platycodins folium and its cytotoxicity

Cuizhu Wanga Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun, China;b School of Pharmaceutical Sciences, Jilin University, Changchun, China
,
Qinghai Dongb School of Pharmaceutical Sciences, Jilin University, Changchun, China
,
Fulin Wub School of Pharmaceutical Sciences, Jilin University, Changchun, China
,
Zhuo Lic Department of Biomedical Sciences, Creighton University, Omaha, NE, America
,
Pingya Lib School of Pharmaceutical Sciences, Jilin University, Changchun, China
,
Jinping Liub School of Pharmaceutical Sciences, Jilin University, Changchun, China
&
Fang Wanga Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun, ChinaCorrespondence[email protected]
 show all
Pages 3487-3493 | Received 05 Jul 2019, Accepted 28 Dec 2019, Published online: 17 Jan 2020
 
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Abstract

A new alkynol, platycodynol (1), identified as 2, 3, 9, 13, 14-pentahydroxy-4, 6-tetradecadiyne, along with six known compounds (2–7) were obtained from Platycodins folium for the first time. Their structures were elucidated with infrared (IR), ultraviolet (UV), 1D and 2D nuclear magnetic resonance (NMR) spectroscopic analysis as well as by high resolution electrospray ionization mass spectroscopy (HRESIMS). Platycodynol showed cytotoxicity against S180, A549 and SPC-A-1 cancer cells but no cytotoxicity against normal cells NCTC1469 and HL-7702 by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method.

Graphical Abstract

Acknowledgments

We thank Chun-Yu Wang, Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, for the measurement of NMR spectra.

Disclosure statement

No potential conflict of interest was reported by the authors.

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