2H-pyranone and isocoumarin derivatives from the endophytic fungus Pestalotiopsis microspora SC3082 derived from Scaevola taccada (Gaertn.) Roxb

Abstract

Two new 2H-pyranones (1 and 2), two new isocoumarins (4 and 5), and two known compounds (3 and 6) were obtained from solid cultures of the endophytic fungus Pestalotiopsis microspora SC3082. Their structures and revision of the absolute stereochemistry of 6 were established by spectroscopic analyses and computational calculations. Compounds 2, 4 and 6 displayed moderate antifungal activities against Candida albicans ATCC 10321 with MIC values of 25.0, 25.0, and 12.5 μg/mL, respectively.

Graphical Abstract

Keywords:

• 2H-pyranone
• isocoumarin
• Pestalotiopsis sp.
• endophytic fungus

Acknowledgements

We gratefully acknowledge support from the Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences, and thank Ai-Jun Sun and Yun Zhang, South China Sea Institute of Oceanology, Chinese Academy of Sciences, for the measurement of HRESIMS.

Disclosure statement

No potential conflict of interest was reported by the authors.

Figure 1. Structures of compounds 1–6.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (21502197 and 81872773), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA13020500), the Science and Technology Planning Project of Guangdong Province, China (2015A020211023) and Youth Innovation Promotion Association of Chinese Academy of Sciences.