Picraquanines A－C, three new phenolic derivatives from the stems of Picrasma quassioides

Abstract

Three new phenolic derivatives, picraquanines A–C (1–3), along with 6 known ones 4–9 were obtained from the stems of Picrasma quassioides (D. Don) Benn. The new structures were determined by extensive spectroscopic data analysis, including IR, HRESIMS, ¹H-NMR, ¹³C-NMR, HSQC, HMBC, ¹H-¹H COSY experiments. The absolute configuration of 1 was determined by comparison of its experimental and calculated ECD spectra. Furthermore, all the compounds were tested for their nitric oxide (NO) inhibitory effects against LPS-stimulated RAW 264.7 cells, however, none of them exhibited inhibitory effects (IC₅₀ >100 μM).

Keywords:

• Picrasma quassioides
• structure determination
• Picraquanines A－C
• NO inhibitory activity

Acknowledgments

The Program of Shanghai Academic/Technology Research Leader (17XD1403500), Excellent Academic Leaders Program of Shanghai (16XD1403500) and the programs of High level University Innovation Team and Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine are acknowledged for supporting this study.

Disclosure statement

There are no competing financial interests reported by the authors.