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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 22
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Short Communications

Phenolic profile by HPLC-ESI-MS/MS and enzymatic inhibitory effect of Bryophyllum delagoense

Edenize Maria Katruchaa Curso de Graduação em Farmácia, Sociedade de Educacional Santa Catariana, UniSociesc, Jaraguá do Sul, SC, BrazilView further author information
,
Jéssica Lopesa Curso de Graduação em Farmácia, Sociedade de Educacional Santa Catariana, UniSociesc, Jaraguá do Sul, SC, BrazilView further author information
,
Milena Paimb Curso de Graduação em Farmácia, Fundação Universidade Regional de Blumenau, FURB, Blumenau, SC, BrazilView further author information
,
Júlia Candiani dos Santosa Curso de Graduação em Farmácia, Sociedade de Educacional Santa Catariana, UniSociesc, Jaraguá do Sul, SC, BrazilView further author information
,
Diogo Alexandre Siebertc Curso de Pós-Graduação em Química, Universidade Federal de Santa Catarina – UFSC, Florianópolis, SC, BrazilORCID Iconhttps://orcid.org/0000-0002-9741-4597View further author information
ORCID Icon,
Gustavo Amadeu Mickec Curso de Pós-Graduação em Química, Universidade Federal de Santa Catarina – UFSC, Florianópolis, SC, BrazilView further author information
,
Luciano Vitalic Curso de Pós-Graduação em Química, Universidade Federal de Santa Catarina – UFSC, Florianópolis, SC, BrazilView further author information
,
Michele Debiasi Albertonb Curso de Graduação em Farmácia, Fundação Universidade Regional de Blumenau, FURB, Blumenau, SC, BrazilORCID Iconhttps://orcid.org/0000-0003-3490-9936View further author information
ORCID Icon &
Adrielli Tenfena Curso de Graduação em Farmácia, Sociedade de Educacional Santa Catariana, UniSociesc, Jaraguá do Sul, SC, BrazilCorrespondence[email protected]
View further author information
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Pages 4824-4827 | Received 30 Sep 2019, Accepted 03 Feb 2020, Published online: 11 Mar 2020
 
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Abstract

Bryophyllum delagoense (Eckl. & Zeyh.) Druce, native to Madagascar, is popularly known as “abyssian cactus” and popularly used in folk medicine as an analgesic and healing agent. The study methodology was divided into the phytochemical study: fractionation and identification of phenolic compounds by HLPC-ESI-MS/MS from the methanolic extract (ME), and fractions (DCMF and EAF) of leaves of B. delagoense, and biological activity with acetylcholinesterase and α-glucosidase inhibition of extracts and fractions by in vitro enzymatic techniques. Twenty-seven phenolic compounds were identified, being the highest concentration of syringic acid (87.848 mg g−1). The DCMF fraction showed the best biological activity for inhibition of α-glucosidase enzyme (0.125 mg mL−1).

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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors are grateful to FURB, UFSC and UNISOCIESC for financial support.

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