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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 22
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A sesquiterpenoid from Ligularia pleurocaulis modulated macrophages polarisation through TLR4 pathway

Yang Hua Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China;b School of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing, People’s Republic of ChinaView further author information
,
Hua Yanga Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of ChinaView further author information
,
Xiaoqian Dinga Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of ChinaView further author information
,
Lijun Taob School of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing, People’s Republic of ChinaView further author information
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Minyan Liua Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China;c Hebei Yiling Academy of Medical Limited Company, Shijiazhuang, People’s Republic of ChinaCorrespondence[email protected] [email protected]
View further author information
&
Chaofeng Zhangb School of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing, People’s Republic of ChinaCorrespondence[email protected] [email protected]
View further author information
Pages 4853-4856 | Received 16 Jan 2020, Accepted 10 Feb 2020, Published online: 31 Mar 2020
 
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Abstract

An eremophilane-type sesquiterpenoid (EPS), 3-oxo-eremophila-1,7(11)-dien-12,8β-olide, has been isolated from anti-inflammatory folk herbs, Ligularia pleurocaulis. The aim of present study is to explore protective effects of EPS on lipopolysaccharide (LPS)-induced inflammatory responses in acute lung injury (ALI). EPS treatments (40 and 80 mg/kg) significantly ameliorated LPS-stimulated pathological changes in lungs. Furthermore, in vivo and in vitro mechanism studies suggest that EPS exerts its protective effects on LPS-induced ALI by regulating macrophage polarisation via suppression of TLR4/MyD88-mediated MAPK and NF-κB signaling pathways, and EPS may be useful for the prevention on ALI in the clinical setting.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation (grants 81573553 and 81803391), the Natural Science Foundation of Jiangsu Higher Education Institutions (grant 18KJB350007), and the Natural Science Foundation of Jiangsu (grant BK20180828).

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