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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 22
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Short Communications

Plumieride exerts anxiolytic-like effect mediated by GABAergic and monoaminergic systems

Ana Paula Dalmagroa Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, Brazil;b Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau – FURB, Blumenau, Santa Catarina, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6969-7473View further author information
ORCID Icon,
Anderson Camargoc Programa de Pós-Graduação em Neurociências, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, BrazilView further author information
,
Priscila Laiz Zimatha Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, BrazilView further author information
,
Tiago José Bonominia Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, BrazilView further author information
,
Ana Lúcia Bertarello Zenib Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau – FURB, Blumenau, Santa Catarina, BrazilView further author information
,
Angela Malheirosa Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, BrazilView further author information
&
Márcia Maria de Souzaa Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, BrazilView further author information
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Pages 4849-4852 | Received 10 Nov 2019, Accepted 15 Feb 2020, Published online: 11 Mar 2020
 
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Abstract

Plumieride (PLU), an iridoid isolated from Allamanda cathartica flowers, has been studied by our research group due to its anti-inflammatory potential, antidepressant-like and anxiolytic-like effects. This research investigated the involvement of GABAergic and monoaminergic systems in the anxiolytic-like effect elicited by PLU. Therefore, mice were pre-treated with GABAergic, serotonergic, adrenergic or dopaminergic receptor antagonists (i.p.), and exposed to Elevated Plus-Maze (EPM) and Open-Field Test (OFT). The preliminary results revealed that PLU (p.o.) possibly interacts with the mentioned systems through the GABAA, GABAB, 5-HT1A, 5-HT3, α1, α2, and D2 receptors.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by UNIVALI, FURB and CAPES.

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