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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 23
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Research Articles

Two new 19-hydroxy bufadienolides with cytotoxic activity from the skins of Bufo melanosticus

Lingjie Menga Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, China;c Department of Biochemistry and Molecular Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Sanhua Lia Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Qinghong Konga Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Mei Wanga Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Xiaoke Zhanga Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Xinting Zhua Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;c Department of Biochemistry and Molecular Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Wei Yua Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Nian Jianga Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Zeli Chunb Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
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Nian Lia Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, ChinaView further author information
&
Yun Liua Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou, China;b Research Center for Medicine & Biology, Zunyi Medical University, Zunyi, Guizhou, China;c Department of Biochemistry and Molecular Biology, Zunyi Medical University, Zunyi, Guizhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8615-4710View further author information
ORCID Icon show all
Pages 4894-4900 | Received 05 Nov 2019, Accepted 03 Mar 2020, Published online: 23 Mar 2020
 
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Abstract

Two new 19-hydroxy bufadienolides, named bufohydrolide A (1) and bufohydrolide B (2), and four known analogs (3-6) were isolated from the aqueous extracts of the skins of Bufo melanosticus. Their structures were established by spectral data analyses, such as UV, IR, 1 D/2D NMR and mass spectra. Compounds 1-6 were evaluated for their cytotoxic activity against SMMC-7721, HT-29 and A549 cells. Noteworthily, all six isolates exhibited various levels of anti-proliferative activities with IC50 values ranging from 0.02 ± 0.0002 to 25 ± 0.5 μM.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by Natural Science Foundation of China (81660611), Youth Science &Technology Personal Growth Project of the Educational Department of Guizhou Province (KY [2018] 230),The Foundation of Zunyi Medical University [F-988, F-972, 20173828], Science & Technology Plan of Zunyi (2018 [18]), Guizhou Provincial Science & Technology Program (QKH [2017]5733-059, QKH [2019]1346), Science & Technology Talent Support Project of the Educational Department of Guizhou Province (KY [2018] 055).

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