Three new diterpenoids from Euphorbia peplus

Abstract

Three new diterpenoids (1–3) (two abietane type diterpenoids and a paralianone type diterpenoid), together with four known compounds (4–7) were isolated from the whole plants of Euphorbia peplus. Their structures were elucidated through spectroscopic analysis and physicochemical characteristics. The cytotoxic activities of compounds 1–7 against five human tumour cell lines were evaluated, however, they were inactive at the concentration of 40 μM. The compound 3 enhanced lysosomal biogenesis with Lyso Tracker staining intensity of 132.6%.

Graphical Abstract

Keywords:

• Euphorbiaceae
• Euphorbia peplus
• ent-abietane diterpenoids
• paralianone diterpenoids

Acknowledgements

We thank Dr. Tiwalade A. Adelakun for his linguistic assistance and Dr. Ding X. for help with Lysosomal biogenesis induction activity assays during the revision of this manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was supported by the National Key R&D Program of China under Grant (number 2018YFA0900600); Open Fund of Shanghai Key Laboratory of Plant Functional Genomics and Resources under Grant (number PFGR201902); Technological leading talent project of Yunnan (2015HA020); National Natural Science Foundation of China under Grant (numbers 21432010; 31872666; 81703393); and Special Fund for Talent Introduction of Kunming Institute of Botany, CAS (to Xin Fang).