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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 21
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Original Articles

Pregnane glycosides from the leaves of Dregea volubilis and their α-glucosidase and α-amylase inhibitory activities

Nguyen Thi Kim Thuya Center for High Technology Development, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet NamView further author information
,
Phan Tuan Phuongb Graduate University of Science and Technology, VAST, Hanoi, Viet NamView further author information
,
Nguyen Thi Thu Hienc Hanoi University of Mining and Geology, Bac Tu Liem, Hanoi, Viet NamView further author information
,
Do Thi Trangd Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet NamView further author information
,
Nguyen Van Huana Center for High Technology Development, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet NamView further author information
,
Phan Thi Lan Anha Center for High Technology Development, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet NamView further author information
,
Bui Huu Taid Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam;b Graduate University of Science and Technology, VAST, Hanoi, Viet NamView further author information
,
Nguyen Xuan Nhiemd Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam;b Graduate University of Science and Technology, VAST, Hanoi, Viet NamView further author information
,
Nguyen The Hunge Department of Traditional Pharmacy, Hanoi University of Pharmacy, Hanoi, Viet NamCorrespondence[email protected]
View further author information
&
Phan Van Kiemd Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam;b Graduate University of Science and Technology, VAST, Hanoi, Viet NamCorrespondence[email protected]
View further author information
 show all
Pages 3931-3938 | Received 28 Dec 2019, Accepted 22 Mar 2020, Published online: 01 Apr 2020
 
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Abstract

Three new pregnane glycosides, drevoluosides O-Q (1-3) along with five known volubiloside C (4), dreageoside A11 (5), 17β-marsdenin (6), stavaroside H (7), and hoyacarnoside G (8) were isolated from the methanol extract of the Dregea volubilis leaves. Their structures were elucidated by chemical and spectroscopic methods. Compounds 6-8 showed significant anti α-glucosidase activity with the inhibitory percentages ranging from 32.6 to 47.1% at the concentration of 200 μM. Compound 3 showed significant inhibitory α-amylase activity with IC50 value of 51.3 ± 2.1 μM.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors

Additional information

Funding

This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.99-2017.340.

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