A new phenylheptanoid from the leaves of Gnetum gnemon L.

Abstract

Phytochemical study on the EtOAC-soluble extract of the leaves of Gnetum gnemon furnished the isolation of a new phenylheptanoid, gnetumal (1), along with five known compounds (2–6). Their isolation was carried out by using the column chromatography and their structures were elucidated based on the basis of the spectral interpretation. Bioactivity assay of these compounds indicated that gnetumal (1) and p-coumaric acid (5) possessed more potent tyrosinase inhibitory activity, with IC₅₀ values of 31.6 and 2.3 µM, respectively, than that of a positive control kojic acid (IC₅₀; 44.6 µM).

Graphical Abstract

Keywords:

• Gnetum gnemon L.
• Gnetaceae
• phenylheptanoid
• tyrosinase inhibitory

Supplementary material

Copies of spectroscopic data for all isolated compounds (1–6).

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research is funded by Vietnam National University Ho Chi Minh City (VNUHCM) under grant number C2018-18-12, to Tho Huu Le.