Cytotoxic triterpenoid glycosides from leaves of Cyclocarya paliurus

Abstract

Three previously undescribed dammarane triterpenoid glycosides (1-3) along with five known analogues (4-8) were isolated from the leaves of Cyclocarya paliurus. Their structures and configurations were determined on the basis of comprehensive spectroscopic analyses, chemical hydrolysis and DFT GIAO ¹³C NMR calculation. All the isolates were evaluated cytotoxic activities against seven human cancer cell lines (MCF-7, PC-3, Du145, NCI-H1975, PC-9, SKVO3 and HepG2). Moreover, compound 4 showed a wide spectrum of cytotoxicity against human cancer cells with IC₅₀ values ranging from 11.31 to 29.51 µM.

Graphical Abstract

Keywords:

• Cyclocarya paliurus
• 3,4-seco-dammarane triterpenoid glycosides
• cytotoxic activities

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Central South University postgraduate independent exploration and innovation project under Grant [No. 2019zzts751; No. 2018zzts239], Central South University College Students Innovation and Entrepreneurship Project under Grant [No. GS201910533126X; No. GS201910533022X; No. XCX20190632], Hunan Province Ordinary Higher Education Teaching Reform Research Project, Central South University Deepening Innovation and Entrepreneurship Education Reform Research Project under Grant [No. 2019CG006], and Hunan Graduate Research and Innovation Project under Grant [No. CX20190247].