Euphopanes A–C, three new diterpenoids from Euphorbia pekinensis

Abstract

Three new diterpenoids, euphopanes A–C (1–3), including one ent-isopimarane (1), one ent-abietane (2) and one cembrane (3), along with five known compounds (4–8) were isolated from the roots of Euphorbia pekinensis. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configurations of compounds 1–3 were determined by ECD calculations. All the isolates were screened for the cytotoxicity against three cancer cell lines (C4-2B, C42B/ENZR, and MDA-MB-231), and compounds 1, 2, and 4 showed significant cytotoxicity against human prostate cancer cells C4-2B with IC₅₀ values of 14.3, 16.9, and 15.3 μM, respectively.

Graphical Abstract

Keywords:

• Euphorbia pekinensis
• cytotoxicity
• diterpenoid
• Euphopane

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by National Natural Science Foundation of China (Nos. 81722042, 81973195 and 81973203).