Paratrimerin I, cytotoxic acridone alkaloid from the roots of Paramignya trimera

Abstract

Bioactivity-guided fractionation of the CHCl₃-soluble extract of the roots of Paramignya trimera was carried out to obtain a new acridone alkaloid, paratrimerin I. Its structure was elucidated based on NMR spectroscopic data interpretation. Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC₅₀ values of 0.43 and 0.26 µM, respectively. The N-methyl, C-4 methoxy, and C-5 hydroxy groups in the acridone skeleton can be proposed as a structural feature for good cytotoxicity.

Graphical Abstract

Keywords:

• Paramignya trimera
• alkaloid
• acridone
• cytotoxicity

Supplementary material

Copies of spectroscopic data (Figure S2–S7) for compounds 1 and 2.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was funded by Viet Nam National University Ho Chi Minh City (VNU-HCM) under grant number 562-2018-18-04, to N.T. Nguyen.