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Abstract
Two new triterpenoid-chromone hybrids, cimitriteromones H (1) and I (2), along with two known analogues (3, 4) were isolated from the phytochemical research on the n-butyl alcohol extracts of Actaea cimicifuga rhizomes. The new compounds were elucidated by spectroscopic experiments and chemical method. The cytotoxic activities of the isolated compounds were tested on A-549/Taxol cell line. Cimitriteromone I (2) showed cytotoxicity with IC50 value of 27.14 ± 1.38 μM comparable to positive control group cisplatin (IC50 value of 25.80 ± 1.15 μM).
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by Autonomous Deployment Project of Kunming Institute of Botany, CAS under Grant No. KIB2017010; Programs of National Natural Science Foundation of China under Grant No. U1132604 and 81302670); and The Major Program of CAS under Grant No. KSZD-EW-Z-004-01.