Licochalcone L, an undescribed retrochalcone from Glycyrrhiza inflata roots

Abstract

Glycyrrhiza inflata Batalin is among the three glycyrrhizin producing Glycyrrhiza species and can be distinguished from other species with regard to its retrochalcone contents. Seven retrochalcones, echinatin and licochalcones A, C, D, E, K, and L were isolated and characterized from the chloroform extract of G. inflata roots. Among the isolates, licochalcone L was found to be previously undescribed. Structure elucidation of these specialised metabolites was achieved through NMR and mass spectroscopic data analyses.

Graphical Abstract

Keywords:

• Licorice/liquorice
• Glycyrrhiza inflata
• liquorice root
• retrochalcone
• licochalcone L
• marker compounds

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research is supported by the “Holistic Approach for Potential Drug Interactions with Botanical Drugs” funded by the Center for Drug Evaluation and Research, U.S. Food and Drug Administration, grant number HHSF223201810175C.