Characterisation of teaghrelin-like principles from Assam tea cultivated in Thailand

Abstract

Teaghrelins were identified as unique acylated flavonoid tetraglycosides and firstly reported in Chin-shin oolong tea. In the present study, two new teaghrelin-like compounds (1 and 2) were purified and characterised from Assam tea varieties collected in Thailand. Their chemical structures were constructed by the spectroscopic and spectrometric analysis. These two teaghrelin-like compounds were also not supposed to exhibit significant ghrelin receptor affinity according to the structural comparison with those teaghrelin-like compounds previously reported. In addition, compounds 1 and 2 did not display notable anti-inflammatory activity in human neutrophils assay.

Keywords:

• Camellia sinensis var. assamica
• Assam tea
• acylated flavonoid tetraglycoside
• spectroscopic and spectrometric analysis
• ghrelin receptor affinity

Acknowledgements

The authors gratefully acknowledge the use of 500NMR of the machine equipment belonging to the Instrument Center of National Cheng Kung University.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The present research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 108-2622-8-005-002-TB1 awarded to JTC Tzen).