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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 23
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Short Communication

Kopsanone and N-oxide isolated from Aspidosperma macrocarpon Mart. (Apocynaceae) leaves and their MAO-A inhibitory activity

Matheus Ardenghi Peixotoa Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, BrazilORCID Iconhttps://orcid.org/0000-0003-4548-8241
ORCID Icon,
Lucilia Katob Instituto de Química, Universidade Federal de Goiás, Goiânia, Goiás, Brazil
,
Cecília Maria Alves de Oliveirab Instituto de Química, Universidade Federal de Goiás, Goiânia, Goiás, Brazil
,
Boniek Gontijob Instituto de Química, Universidade Federal de Goiás, Goiânia, Goiás, Brazil
,
Cleuza Conceição da Silvaa Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil
,
Armando Mateus Pominia Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, BrazilORCID Iconhttps://orcid.org/0000-0001-5296-7895
ORCID Icon,
Luiz C. Klein-Júniorc Faculdade de Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
,
Carolina dos Santos Passosc Faculdade de Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
,
Amélia T. Henriquesc Faculdade de Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
,
Geanderson Bannwarta Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil
&
Silvana Maria de Oliveira Santina Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4809-3205
ORCID Icon show all
Pages 5465-5469 | Received 15 Oct 2019, Accepted 04 Jun 2020, Published online: 22 Jun 2020
 
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Abstract

Aspidosperma macrocarpon Mart., popularly known as ‘guatambu’ or ‘peroba’, is found from North American (Mexico) to South American (Argentina) continents and in Brazil. Two indole alkaloids were isolated from leaves of A. macrocarpon, kopsanone (1) and unreported N(4)-oxide-kopsanone (2).

Graphical Abstract

Supplementary material

Experimental details, Figure S1 to S15 and Table S1 and S2 are available online.

Acknowledgements

This research was supported by CAPES and we thank Aristonio Magalhães Teles for assistance with plant material photography.

Disclosure statement

No potential conflict of interest was reported by the authors.

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