Benzofuran derivatives with nerve growth factor-potentiating activity from Phellinus ribis

Abstract

Three new benzofuran derivatives, namely ribisin E (1) ribisin F (2) along with ribisin G (3) were isolated from the MeOH extract of the fruiting bodies of Phellinus ribis. Their structures were elucidated based on the NMR analysis. Furthermore, the absolute configuration of ribisin E (1) and ribisin G (3) were deduced by the CD calculations, and the absolute configuration of ribisin F (2) was determined by comparing its CD spectrum and specific rotation with the data of known analogues. All compounds (1–3) exhibited the activity of promoting neurite outgrowth in nerve growth factor (NGF)-ediated PC 12 cell at concentrations ranging from 1 to 30 μM.

Graphical Abstract

Keywords:

• Phellinus ribis
• benzofuran derivatives
• NGF-potentiating activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China (81973218), the Natural Science Foundation of Shandong Province (ZR2019MH082) and the Postdoctoral Foundation from Prof. Fukuyama in Tokushima Bunri University.