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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 2
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Research Articles

A new benzofuran glycoside from the fruit of Clausena lansium

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Pages 501-507 | Received 17 Feb 2020, Accepted 14 Jun 2020, Published online: 08 Jul 2020
 

Abstract

In this work, we isolated a new benzofuran glycoside, 6-β-d-glucosyl-6,7-dihydroxy-5-benzofuranpropanoic acid methyl ester (1), together with six known compounds (27) from the fruits of Clausena lansium (Lour.) Skeels. Extensive spectroscopic methods were employed to elucidate their structures. Herein, compounds 2, 3, 5 and 6 were reported from Clausena lansium (Lour.) Skeels for the first time. Moreover, compounds 1, 2, 4 and 6 showed comparable 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity to l-ascorbic acid, and compound 4 also exhibited potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and ferric reducing antioxidant power (FRAP). All of the compounds showed oxygen radical absorbance capacity (ORAC) values ranging from 0.3 to 3.6 μmol trolex equivalent/μmol. In addition, compounds 3 and 5 also demonstrated good α-amylase inhibitory activity.

Acknowledgements

We have special thanks to associate Prof. Taotao Li, South China Botanical Garden, Chinese Academy of Science, for the identification of Clausena lansium. We also thank Prof. Jianwei Chi and doctor Qin Ma, Sericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences, for helpful suggestions and discussions.

Disclosure statement

The authors declare that there are no conflicts of interest.

Additional information

Funding

We are grateful for the National Key R&D Program of China (No 2018YFC1602102-2) Ministry of Science and Technology of China, Guangdong special support program (2019BT02N112), Natural Science Foundation of Guangdong Province (2018A030310199), the President Foundation of Guangdong Academy of Agricultural Sciences (No. 201904). Special fund for scientific innovation strategy–construction of high-level Academy of Agriculture Scinece (NO.R2017YJ-YB2006; R2018QD-081).

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