Abstract
The antifungal activity of Pelargonium capitatum essential oil (PCEO) and Cymbopogon martini essential oil (CMEO) against C.albicans were evaluated. The main components of essential oils were β-cytronellol 58.81% and geraniol 83.94% in PCEO and CMEO, respectively. PCEO was more activity than CMEO for all C.albicans strains tested with values MIC50 or MIC90 of 780 µg/ml. PCEO used in combination with fluconazole or CMEO shows synergistic effect with FICI values ≤ 0.5. Moreover both essential oils are able to inhibit the major virulence factor of C.albicans as the germ tube formation at sub-inhibitory concentration of 195 µg/ml. In conclusion, it is possible to hypothesize that PCEO can be used in combination with fluconazole or CMEO. Further studies are in due course to confirm these results.
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Disclosure statement
The authors declare that they have no conflict of interests.