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Abstract
A new diarylhexane, kneglobularone B (1) and two new diarylpropanols, kneglobularols A − B (2 − 3) along with seven known compounds (4 − 10) were isolated and characterized from the roots of Knema globularia. It is the first time to find arylpropyl quinone (4) and isoflavone (8) in Myristicaceae family. In addition, 5 was found for the first time in Knema genus. Their structures were elucidated by UV, IR, MS, 1 D and 2 D NMR techniques. Compound 4 exhibited strong cytotoxicity against the NCI − H187 and MCF − 7 cell lines with IC50 values of 3.08 and 6.68 µg/mL, respectively.
Graphical Abstract
Acknowledgements
We thank the TRF Grant for New Researcher (grant no. TRG5780170) and Roi Et Rajabhat University for their financial support. We are thankful for The Natural Product Research Unit, Department of Chemistry, Faculty of Science, Khon Kaen University, and the Center of Excellence for Innovation in Chemistry (PERCH − CIC), Office of the Higher Education Commission, Ministry of Education, Thailand for kindly providing the research facilities. The Bioassay Laboratory of the National Center for Genetic Engineering and Biotechnology, Pathumthani, Thailand, for biological activity assays is gratefully acknowledged.
Disclosure statement
No potential conflict of interest was reported by the authors.