Trichocladabiflavone A, a chalcone-flavonone type biflavonoid from Selaginella trichoclada Alsto

Abstract

A chalcone-flavonone type biflavonoid, trichocladabiflavone A (1), along with eight known biflavonoids (2–9) were isolated from the 70% EtOH extract of Selaginella trichoclada. Their structures were elucidated by extensive spectroscopic analyses. Compound 1 was the first chalcone-flavonone type biflavonoid reported in the genus Selaginella. Moreover, compound 1 exhibited moderate cytotoxicity against DU145, MCF-7 and PC3 human cancer cell lines.

Graphical Abstract

Keywords:

• Selaginella trichoclada
• biflavonoids
• trichocladabiflavone A
• chalcone-flavonone

Acknowledgements

The authors gratefully acknowledge the NMR measurements from the Modern Analysis and Testing Centre of CSU.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The work was financially supported by the National Natural Science Foundation of China (Nos. 31700303 and 31370370).