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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 24
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Research Articles

Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell

Tjitjik Srie TjahjandarieNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaCorrespondence[email protected]
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,
Mulyadi TanjungNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaView further author information
,
Ratih Dewi SaputriNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaView further author information
,
Devina Oktari RahayuNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaView further author information
,
Alfiah Nur Irza GunawanNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaView further author information
&
Muhammad Fajar AldinNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaView further author information
Pages 5637-5642 | Received 09 Apr 2020, Accepted 28 Aug 2020, Published online: 18 Sep 2020
 
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Abstract

Two new 2-arylbenzofurans, sesbagrandiflorain D (1) and E (2) along with two known 2-arylbenzofurans, spinosan A (3) and spinosan B (4) were isolated from the stem bark of Sesbania grandiflora L. The structure of two new compounds established by HRESIMS, 1 D NMR (1H, 13C) and 2 D NMR (HMQC, HMBC) spectra. Compounds (1-4) assayed for their cytotoxicity towards three human cancer cells (MCF-7, HeLa, and WiDr). Compound 1 showed very high activity against MCF-7 and WiDr with an IC50 value of 0.06 and 0.60 μg/mL, respectively.

Graphical Abstract

Supplementary material

HRESIMS, 1 D, and 2 D NMR spectra reported in the supplementary materials as Figure S1–S12 and related to the following articles are available online.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This research supported by Fundamental Research Grant (Penelitian Dasar), 2019, Universitas Airlangga, Surabaya.

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