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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 24
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Research Articles

Anti-inflammatory Dendranacetylene A, a new polyacetylene glucoside from the flower of Chrysanthemum morifolium Ramat

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Pages 5692-5698 | Received 07 Jun 2020, Accepted 04 Sep 2020, Published online: 29 Sep 2020
 

Abstract

A new polyacetylene glucoside, Dendranacetylene A (1), and a known compound 8E-decaene-4,6-diyn-1-O-β-d-glucopyranosyl-(1ʺ→2ʺ)-β-d-glucopyranoside (2) were isolated from the flowers of Dendranthema morifolium (Ramat.) kitam. The chemical structures of these compounds were elucidated by NMR and HR-ESI-MS analysis, and comparing these results with data reported in literatures. Additionally, the anti-inflammatory effects of compounds 1 and 2 were evaluated on RAW264.7 murine macrophage cells induced by lipopolysaccharide (LPS). The two compounds significantly inhibited the NO production in LPS-induced RAW 264.7 murine macrophage cells and exhibited anti-inflammatory effects.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Our work was supported by the Central Government Guide Local Science and Technology Development Funds (14104349), the Key Scientific Research Project of Institutions of Higher Learning in Henan (21B360003), the Special Project of Scientific Research on Traditional Chinese Medicine in Henan (20-21ZY2151) and the Doctoral Research Fund of Henan University of Chinese Medicine (BSJJ2018-08).

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