A new benzophenone with biological activities purified from Aspergillus fumigatus SWZ01

Abstract

Strain SZW01 was isolated from sea sediment collected from Shenzhen in Guangdong province, China, and was later identified as Aspergillus fumigatus by16S rDNA sequence analysis. Various chromatographic processes led to the isolation and purification of three compounds from the fermentation culture of SZW01, including a new compound, 2,6'-dihydroxy-2,4'dimethoxy-8'-methyl-6-methoxy-acyl-ethyl-diphenylmethanone (1), and two known compounds: fumigaclavine C (2) and alternarosin A (3), as characterised by UV, IR, 1 D, 2 D-NMR and MS data. The antioxidant and α-glucosidase inhibitory activities of these compounds were evaluated. The result illustrated that compound 1 exhibited a moderate antioxidant activity and stronger α-glucosidase inhibitory activity than acarbose.

Keywords:

• Benzophenone
• antioxidant activity
• α-glucosidase inhibitory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Postdoctoral support plan of Harbin University of Commerce [grant No. 2017BSH003], University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [grant No. UNPYSCT-2018140], Harbin University of Commerce “Young Innovative Talents” Support Program [grant No. 2019CX38], Harbin University of Commerce Doctoral Research Startup Fund [grant No. 2019DS111], Harbin University of Commerce “Young Innovative Talents” Support Program [grant No. 2019CX09].