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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 24
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Short Communications

Campomanesia xanthocarpa (Mart.) O. Berg essential oil induces antileishmanial activity and remodeling of the cytoplasm organelles

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Pages 6112-6116 | Received 07 May 2020, Accepted 05 Sep 2020, Published online: 01 Oct 2020
 

Abstract

Leishmaniasis is a neglected disease that affects millions of people worldwide. This study aimed to analyze antileishmanial activity of Campomanesia xanthocarpa leaf essential oil (EO) on promastigote and amastigote forms of Leishmania amazonensis, cytotoxicity in murine macrophages and sheep erythrocytes. The essential oil (EO) was analyzed by gas chromatography/mass spectrophotometry. The main and most abundant compounds were sesquiterpene hydrocarbons (71.22%) such as trans-caryophyllene (7.87%), bicyclogermacrene (11.28%), and δ-cadinene (8.34%). The IC50 for promastigote and amastigote forms of L. amazonensis was 70 µg mL−1 and 6 µg mL−1, respectively. C. xanthocarpa EO was not cytotoxic for murine macrophages (CC50 1860 µg mL−1) and sheep erythrocytes (1.5%), presenting high selectivity index for protozoan (310). C. xanthocarpa EO induced effects on the morphology and ultrastructure of this parasite. The high activity for intracellular amastigote forms, low toxicity to murine macrophages, and erythrocytes, suggest that C. xanthocarpa EO is promising for the treatment of leishmaniasis.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was financed in part by Fundação Araucária the Coordenaçáo de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) Finance Code 001.

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