Berberisides A-D: three novel prenylated benzoic acid derivatives and a clerodane glycoside from Berberis tsarica aherndt.

Abstract

Three undescribed prenylated benzoic acid derivatives berberisides A-C (1-3) and a new clerodane glycoside berberiside D (4) were isolated from Berberis tsarica Aherndt. Their structures were elucidated on the basis of extensive NMR and HR-ESI-MS analysis. The in vitro cytotoxic activities of all isolates were studied against lung carcinoma A549, hepatocellular carcinoma HepG2 and breast carcinoma MDA-MB-231 cell lines. Among them, compounds 1 and 4 exhibited anti-proliferative effects against three tumor cell lines with IC₅₀ ranging from 28.97 ± 2.18 to 35.83 ± 0.72 μM.

Graphical Abstract

Keywords:

• Berberis tsarica Aherndt.
• Berberisides A-D
• diterpene
• prenylated benzoic acids
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by National Natural Science Foundation of China (No. 81774005), Innovative Research Project for Postgraduate Students of Chongqing (No. CYS19099), Chongqing Social Undertaking and Livelihood Security Project (No. cstc2017shmsA130079).