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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 8
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Research Articles

Isolation of a new monoterpenoid glycoside from Anhua dark tea based on an NMR-guided method and its cytotoxic activity against MDA-MB-231 and SH-SY5Y cell lines

Yunqiang Zhanga School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China;d Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
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Jianyu Liuc School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China;d Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, ChinaORCID Iconhttps://orcid.org/0000-0003-0714-1319View further author information
ORCID Icon,
Miao Chena School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China;d Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
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Yanhua Fanb State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, ChinaView further author information
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Meichen Lia School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China;d Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
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Andong Wange School of Pharmacy, Nantong University, Nantong, ChinaView further author information
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Gaigai Liuc School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China;d Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
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Yongnan Xuc School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China;d Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
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Xuhong Renc School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China;d Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected] [email protected]
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Yan Xiaoc School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China;d Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected] [email protected]
View further author information
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Pages 2015-2020 | Received 23 Aug 2020, Accepted 16 Oct 2020, Published online: 04 Nov 2020
 
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Abstract

Based on an NMR-guided method, one new monoterpenoid glycoside (1) was isolated from Anhua dark tea, together with five known compounds (2–6). The structure of the new compound was determined as 3-(5,5-dimethyltetrahydrofuranyl)-1-buten-3-ol primeveroside, and trivially named anhuaterpenoside A (1), on the basis of detailed spectroscopic analyses, and acidic hydrolysis. Compound 1 exhibits cytotoxic activity against MDA-MB-231 and SH-SY5Y cell lines with IC50 value of 23.26 μM and 18.57 μM, respectively.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the general project of Department of Education of Liaoning Province (grant no 2019LJC13), Science and Technology Project of Gansu Province (grant no 18YF1NA128) as well as the National Undergraduate Training Program for Innovation and Entrepreneurship (202010163027).

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