Two new phenolic glucosides from marine-derived fungus Aspergillus sp.

Abstract

Two new phenolic glucosides, including a new O-glycoside (1) and a new C-glycoside (2), were isolated from a marine-derived fungus Aspergillus sp. The structures of new compounds were elucidated through interpretations of spectroscopic evidence and high-resolution electrospray ionization mass spectrometry. The hexose unit of 1 was identified as β-D-glucose by comparison with an authentic sample via HPLC after acid hydrolysis and derivatization. All compounds were evaluated for their ability to inhibit LPS-induced NO production in RAW264.7 macrophages, but none of them displayed significant activity.

Graphical Abstract

Keywords:

• Aspergillus sp
• phenolic
• glucoside

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the [Program for Changjiang Scholars of the Ministry of Education of the People’s Republic of China] under Grant [No. T2016088]; [the National Natural Science Foundation for Distinguished Young Scholars] under Grant [No. 81725021]; [Gannan Medical University] under Grant [QD201832]; [Health and family planning committee of Jiangxi province] under Grant [2015B031]; [the Jiangxi Education Hall Science and Technology Foundation] under Grant [GJJ190829]. We thank the Analytical and Testing Center at Huazhong University of Science and Technology for assistance in the acquisition of the ECD, UV, and IR spectra.